克罗米酚对男性低促性腺素性功能减退症合理

纽约（费希尔社健康原版）1年初四日报道：据发表在12年初出原版的《分娩与不孕》月刊的一项简报声称克罗米酰对部分高促病态腺芝病态功能减退的男病态病症利于。来自伯明翰佐治亚大学的该简报的第一编者Scott J. WhittenDr在给与费希尔通讯社记者时说：“原发病态或获得病态HH病症在给与侵害病态更大和更加昂贵的病人（例如注射促病态腺激芝类）前开展4个年初的克罗米酰试验病态病人是利于的。”WhittenDr和威尔森研究了克罗米酰对10名HH男病态病症（HH是导致男病态不孕的普遍各种因芝）是否有效。简报称克罗米酰病人1年后，4名贝尔(氏)症病症中只有一名病症的生殖浓度增高而全输卵管功能减退症病症的生殖不够症状均并未得到改善。相反，该简报声称3名成年发病的原发病态HH男病态病症经过3个年初克罗米酰的病人生殖浓度有了明显增高。目前为止该组病症已为两名恢复了分娩能力。WhittenDr说：“除非对克罗米酰病人并未重排，我们不会因为类药物暂时中止对病症使用该药物。”就此编者概述说：“因为条件有限，对HH病症促病态腺激芝类药物和克罗米酰的随机研究难以开展，然而借助多第四部的严格选择规范对病症开展国际标准可能设法促使验证克罗米酰恢复男病态高分娩能力的有效病态。 Male Hypogonadotropic Hypogonadism May Respond to Clomiphene CitrateBy Will Boggs, MDNEW YORK (Reuters Health) Jan 04 - Some men with hypogonadotropic hypogonadism (HH) benefit from treatment with clomiphene citrate, according to a report in the December issue of Fertility and Sterility.Patients with idiopathic or acquired HH "may benefit from a 4-month trial (of clomiphene citrate) before proceeding with more invasive and expensive therapies, such as injectable gonadotropins," lead author Dr. Scott J. Whitten, from University of Alabama at Birmingham, told Reuters Health.Dr. Whitten and colleagues investigated whether 10 men with HH, a rare cause of male infertility, might respond to treatment with clomiphene citrate.Only one of four patients with Kallmann's syndrome experienced an improvement in sperm concentration after 1 year of therapy with clomiphene citrate, the authors report, and no patient with panhypopituitarism experienced a reversal of azoospermia with clomiphene citrate treatment.In contrast, all three men with -onset idiopathic HH experienced significant increases in sperm concentrations and testosterone levels after 3 months of therapy with clomiphene citrate, the report indicates. Two pregnancies he been achieved in this subgroup so far."We did not he any of our patients discontinue the clomiphene because of side effects, only if there was lack of response," Dr. Whitten said."Because this is such a rare condition, additional randomized studies comparing gonadotropins with clomiphene in this subtype of HH patients would be difficult to perform," the authors conclude. "However, larger series using strict inclusion criteria for stratifying patients may be helpful to further examine the success of clomiphene treatment in restoration of this form of male subfertility."Fertil Steril 2006;86:1664-1668.

主编：蓝色幻想

主编： 张靖